Job Overview:
You will join a Blood Cancer UK-funded project to further understand the mechanisms underlying the activation of cancer signalling pathways by tyrosine fusion kinases in Leukemia. This is a fixed-term position until June 2028. As a Research Technician, you will carry out large-scale recombinant protein production to support the structural biology aspects of this project and perform subsequent biochemical and biophysical assays to probe new allosteric approaches to inhibit fusion kinase function.
About Our School:
The Genome Damage and Stability Centre is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability, and its relationship to disease. We provide a stimulating and supportive environment and are committed to the University’s core values of kindness, integrity, inclusion, collaboration, and courage.
Check out – Warehouse Operative (Visa Sponsorship Available)
Key Responsibilities:
- Carry out large-scale recombinant protein production.
- Perform subsequent biochemical and biophysical assays to probe assembly and activity of fusion kinases.
- Work independently and collaboratively as part of a multidisciplinary research team and a wider network of academic and clinical collaborators.
- Actively participate in scientific discussions and contribute to the dissemination of research.
About You:
- You should have completed a BSc (and preferably an MSc) degree in Structural biology, Biochemistry, Molecular biology, or a related field.
- You must have hands-on experience in large-scale recombinant protein expression in bacterial or insect cells and subsequent large-scale protein purification techniques.
- Practical experience in biochemical and/or biophysical assays to study protein-protein interactions and enzymatic activity would be advantageous.
- You should bring the enthusiasm, initiative, and organizational skills needed to drive the project forward.
- Excellent written and oral communication skills are essential.
Work Permissions:
This role is eligible for sponsorship only for candidates who already have an existing Skilled Worker sponsorship which either began before April 4, 2024, or began before July 22, 2025, and they are also able to use tradeable points to lower the salary requirement.
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